Kendall Jenner and the Rise of NAD+ in Celebrity Wellness
In a 2022 episode of The Kardashians, Kendall Jenner and Hailey Bieber were shown receiving NAD+ IV infusions, with Jenner stating it brought her comfort during her recovery from post-COVID symptoms. This moment thrust NAD+ therapy into the mainstream spotlight, but the practice has been gaining traction among the Hollywood elite for years. Celebrities like Jennifer Aniston, Gwyneth Paltrow, and Joe Rogan have also publicly endorsed various forms of NAD+ supplementation. While celebrity endorsement often boosts popularity, it also raises important questions about the science behind these treatments and whether they live up to the hype.
What is NAD+ and How Does it Function?
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme found in every living cell of the body. It plays a crucial role in numerous metabolic processes, including energy production, DNA repair, and gene expression. As a person ages, NAD+ levels naturally decline, and this reduction is associated with cellular aging and age-related health conditions. The idea behind NAD+ therapy is to replenish these dwindling levels, theoretically boosting cellular function and combating the effects of aging.
Methods of NAD+ Administration
The delivery method is a key factor in NAD+ therapy, with different approaches offering varying levels of bioavailability and convenience.
- IV Therapy: This method, used by Kendall Jenner and Hailey Bieber, involves administering NAD+ directly into the bloodstream through an intravenous drip. Proponents claim this bypasses the digestive system for maximum absorption, potentially offering faster and more potent effects. However, it is an invasive, time-consuming, and expensive procedure.
- Oral Supplements: Many NAD+ precursor supplements, such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), are available in capsule or powder form. These are a more accessible and convenient option, though absorption may be less efficient than with IV therapy.
- Injections and Patches: Other methods, including subcutaneous injections and transdermal patches, are also available, offering different absorption rates and user experiences.
The Reported Benefits vs. Scientific Scrutiny
While NAD+ therapy is promoted with a wide array of potential benefits, the science behind many of these claims is still evolving. Anecdotal evidence and small studies suggest positive outcomes, but larger, more robust clinical trials are needed.
Potential Benefits
- Enhanced Energy and Vitality: NAD+ is critical for cellular energy production, so boosting its levels may lead to increased energy and reduced fatigue.
- Anti-Aging Effects: By assisting with DNA repair and mitochondrial function, NAD+ therapy is marketed to combat cellular aging.
- Improved Cognitive Function: Some users report enhanced mental clarity, focus, and memory.
- Mood Regulation: NAD+ may play a role in neurotransmitter function, potentially helping with mood regulation.
- Metabolic Health: Studies in animal models and some small human trials have suggested a link between NAD+ and improved metabolic markers like insulin sensitivity.
The Scientific Reality
Despite the positive anecdotes, experts urge caution. Dr. Richina Bicette-McCain notes that claims have not been validated by the FDA, and there is no guarantee of safety or efficacy. Dr. Seres points out that flushing, often seen as a sign that NAD+ is working, is merely a side effect of niacin and not proof of positive effects. Recent research, such as a 2025 study in Cell Metabolism, even challenged the notion that NAD+ decline is the primary driver of muscle aging, raising questions about the supplement's effectiveness in this area. Without long-term, large-scale randomized controlled trials, the true impact of supplemental NAD+ remains uncertain.
IV vs. Oral NAD+ Therapy: A Comparison
| Feature | NAD+ IV Therapy | Oral NAD+ Precursors (e.g., NR/NMN) |
|---|---|---|
| Delivery Method | Direct intravenous infusion | Oral supplement (capsule or powder) |
| Bioavailability | High (near 100%) due to bypassing the digestive system | Varies; must be absorbed by the digestive system |
| Cost | Very high (hundreds to thousands of dollars per session) | More accessible and affordable |
| Invasiveness | Invasive (requires a needle) | Non-invasive (swallowing a pill) |
| Speed of Action | Potentially faster effects due to direct bloodstream entry | Slower onset, requires consistent use over weeks or months |
| Convenience | Less convenient; requires a clinic visit | Highly convenient for daily use at home |
| Risks | Higher risk of infection, bad reactions, and vitamin toxicity | Milder side effects, but long-term safety data is limited |
Important Considerations and Risks
Before considering NAD+ therapy, it is crucial to weigh the potential benefits against the risks and limitations. Costs can be exorbitant, particularly for IV treatments, and results are not guaranteed.
Furthermore, there are documented risks associated with IV therapy. In 2018, Kendall Jenner was hospitalized after experiencing a bad reaction to a different vitamin IV drip, highlighting the inherent risks involved, even for seemingly simple infusions. For NAD+ therapy, side effects can include nausea, flushing, and headaches. In a largely unregulated market, finding a reputable clinic with certified staff is essential to minimize the risk of infection and complications.
Conclusion: Navigating the NAD+ Trend
Yes, Kendall Jenner has publicly confirmed her use of NAD+ IV therapy, positioning herself among other celebrities in the burgeoning biohacking and longevity space. However, the decision to pursue such a therapy should be based on robust medical advice and a realistic understanding of the current scientific evidence, rather than celebrity endorsements alone. While NAD+ plays a vital role in cellular function, large-scale studies are still needed to definitively prove the efficacy and long-term safety of supplemental NAD+ in humans.
For most people, evidence-based approaches to health—like a nutritious diet rich in B3 vitamins (found in foods like turkey, peanuts, and mushrooms), regular exercise, and stress management—are a more accessible and scientifically supported way to support NAD+ levels naturally. Always consult with a healthcare provider before adding any new supplement to your routine.
For more information on the debate surrounding NAD+ supplementation, see this article from National Geographic: What is NAD+? Experts weigh in on the 'miracle molecule' celebrity trend.
