What is the Major Cause of Death in Thalassemia Major?
•
4 min read
Despite significant advancements in treatment, heart disease caused by chronic iron overload remains the leading cause of death for patients with **thalassemia major**. This life-threatening complication stems from the accumulation of excess iron acquired through the frequent blood transfusions necessary to manage severe anemia. Without effective iron chelation therapy, this buildup leads to heart damage that is often fatal.