Understanding What Is the Relationship Between Clearance and VD?
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4 min read
According to pharmacokinetic principles, the elimination half-life of a drug is fundamentally determined by the interplay between its clearance (CL) and its volume of distribution (VD). Understanding **what is the relationship between clearance and VD** is therefore crucial for predicting a drug's duration of action and designing safe and effective dosing regimens. While independent parameters, their combined effect dictates how long a drug remains active in the body.