Tag: Igg4 related disease

According to research published in *Nature Reviews Cancer*, fibroinflammation refers to the highly integrated fibrogenic and inflammatory responses mediated by immune cells and fibroblasts. This complex biological process, which answers the question: **What is a fibro-inflammatory condition?**, highlights how chronic inflammation can drive the excessive buildup of fibrous tissue.

Affecting approximately 1 in 200,000 people per year, retroperitoneal fibrosis (RPF) is a rare disorder characterized by the development of excessive fibrous tissue. This aggressive inflammation raises a crucial question for patients and clinicians alike: is retroperitoneal fibrosis an autoimmune disease? The answer is nuanced, with a significant link to immune system dysfunction.

A majority of retroperitoneal fibrosis cases, approximately 70%, are idiopathic, meaning their origin is unknown. However, further research has shed light on a specific immune-mediated disorder that is now understood to be a significant contributor, altering our understanding of what is the most common cause of retroperitoneal fibrosis?.

It is estimated that up to 40% of submandibular gland tumors are malignant, which makes the diagnosis of a benign lesion like Kuttner's tumor critical. Understanding what is Kuttner's tumor and how it differs from more serious conditions is essential for proper management. This comprehensive guide details the key aspects of this often-misunderstood inflammatory disease.

Originally described in 1888, Mikulicz syndrome is a condition characterized by the painless, symmetrical enlargement of the lacrimal (tear) and salivary glands. Historically, the term was applied to this specific presentation, but modern medicine now considers it a manifestation of a broader systemic disease, most commonly linked to an IgG4-related condition.