Tag: Pretzel syndrome

According to The Dysautonomia Project, the 'pretzel legs phenomenon' is a sign of orthostatic intolerance, a real medical issue. However, the term 'pretzel leg syndrome' is not a formal medical diagnosis but a descriptive phrase referring to the involuntary leg movements of conditions like Restless Legs Syndrome (RLS), the postural adjustments made to manage low blood pressure, or a rare genetic disorder.

Affecting primarily individuals within the Old Order Mennonite community, pretzel syndrome, also known as Polyhydramnios, Megalencephaly, and Symptomatic Epilepsy (PMSE), is a rare and severe genetic disorder. Discovering the answer to "What is the pretzel disease in humans?" reveals a complex, multisystem condition with significant neurodevelopmental consequences.