Tag: Thrombotic microangiopathy

Before modern treatment like plasma exchange was introduced, thrombotic thrombocytopenic purpura (TTP) had a mortality rate approaching 90%. The core element of the pathophysiology of TTP is a severe deficiency of the enzyme ADAMTS13, which allows for widespread, uncontrolled microvascular clotting.

Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening blood disorder characterized by tiny blood clots forming throughout the body. When these clots affect abdominal organs, it can lead to severe pain and other gastrointestinal symptoms, which is what TTP means in the context of the abdomen.

Affecting only a handful of people per million, thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal blood disorder, not a malignancy. A proper diagnosis is critical because its symptoms can overlap with those of other serious conditions, including certain types of cancer.