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What Disease Makes You Very Cold? Understanding the Causes of Cold Intolerance

4 min read

According to the American College of Rheumatology, up to 5% of the U.S. population may experience Raynaud's phenomenon, a condition causing extreme cold sensitivity in the fingers and toes, which is one example of what disease makes you very cold. However, many other conditions can also trigger this symptom.

Quick Summary

This article explores medical conditions, including hypothyroidism, anemia, and poor circulation disorders, that can cause significant cold intolerance and an exaggerated sensitivity to low temperatures.

Key Points

  • Hypothyroidism is a major cause of cold sensitivity: An underactive thyroid gland slows metabolism, reducing the body's heat production and leading to a constant feeling of cold.

  • Anemia affects oxygen transport: A lack of healthy red blood cells, often due to iron or B12 deficiency, hinders oxygen transport needed for warmth, especially in the hands and feet.

  • Raynaud's phenomenon causes episodic coldness: This condition involves extreme narrowing of blood vessels in the fingers and toes in response to cold or stress, causing numbness and color changes.

  • Poor circulation can cause cold extremities: Conditions like Peripheral Artery Disease (PAD), caused by plaque buildup, can restrict blood flow to the limbs, making them feel cold.

  • Other factors can contribute to cold intolerance: Low body weight, certain medications, chronic illnesses like fibromyalgia or diabetes, and malnutrition can also lead to increased cold sensitivity.

  • Diagnosis by a doctor is crucial: If you experience new, severe, or persistent cold intolerance, consulting a healthcare provider is essential to determine the underlying cause and find the right treatment.

In This Article

Causes of Extreme Cold Sensitivity

Experiencing a persistent and unusual feeling of being cold, even in comfortable temperatures, can be more than just a personal tendency; it can be a sign of an underlying medical condition. This abnormal sensitivity, known as cold intolerance, can be caused by disruptions to the body's natural temperature regulation system, which involves the endocrine, circulatory, and nervous systems. While mild cases may be due to simple factors like low body weight, more severe or persistent sensitivity often points to a specific health issue that requires diagnosis and treatment.

Hypothyroidism: An Underactive Thyroid

One of the most common answers to the question "what disease makes you very cold?" is hypothyroidism. This condition occurs when the butterfly-shaped thyroid gland in the neck doesn't produce enough thyroid hormones, which are essential for regulating metabolism. A slow metabolism means the body produces less heat, leading to a constant feeling of being cold.

Symptoms of hypothyroidism develop slowly and may include:

  • Fatigue and lethargy
  • Weight gain
  • Dry skin and hair
  • Depression or low mood
  • Constipation
  • Slow heart rate

The most common cause of hypothyroidism in iodine-sufficient countries is Hashimoto's thyroiditis, an autoimmune disease where the body attacks the thyroid gland. Diagnosis typically involves a blood test to check levels of thyroid-stimulating hormone (TSH) and thyroxine (T4). Treatment usually consists of taking daily synthetic thyroid hormone replacement tablets.

Anemia: Lack of Healthy Red Blood Cells

Anemia is a condition characterized by a lack of healthy red blood cells or hemoglobin, the protein that carries oxygen throughout the body. Red blood cells are crucial for transporting oxygen to tissues, a process vital for energy production and generating body heat. Without enough oxygen circulating, a person with anemia may feel cold, particularly in the hands and feet.

There are several types of anemia, often caused by deficiencies in iron or vitamin B12. Symptoms beyond cold sensitivity can include:

  • Extreme fatigue and weakness
  • Pale or yellowish skin
  • Shortness of breath
  • Dizziness
  • Headaches
  • Brittle nails

Diagnosis requires a complete blood count (CBC) to measure red blood cells and hemoglobin levels. Treatment varies depending on the underlying cause, from dietary changes and supplements to addressing internal bleeding.

Raynaud's Phenomenon: Vasospasm in Extremities

Raynaud's phenomenon is a condition where small blood vessels, usually in the fingers and toes, overreact to cold temperatures or stress by constricting more than they should. This temporary vasospasm restricts blood flow, causing the affected digits to feel cold and numb and turn white or blue. As blood flow returns, the area may tingle, throb, or turn red.

There are two main types:

  • Primary Raynaud's: The more common type with no known cause, generally milder.
  • Secondary Raynaud's: Caused by an underlying medical condition, such as lupus, scleroderma, or carpal tunnel syndrome, and can be more serious.

Management focuses on avoiding triggers, wearing warm clothing, and managing stress. For more severe cases, medications that relax blood vessels may be prescribed.

Poor Circulation and Other Vascular Issues

If the blood supply to the extremities is compromised, the hands and feet can feel constantly cold. This can be a symptom of an underlying circulatory issue, rather than a condition in itself. Conditions like Peripheral Artery Disease (PAD), where plaque buildup narrows arteries, or blood clots can severely restrict blood flow.

Other causes contributing to poor circulation and cold sensitivity include:

  • Diabetes: High blood sugar can damage nerves (neuropathy) and blood vessels, leading to reduced circulation, especially in the feet.
  • Certain Medications: Some medications, including beta-blockers and certain antidepressants, can cause cold extremities by affecting blood flow.
  • Low Body Weight: Individuals with very little body fat have less insulation, making them more susceptible to feeling cold.

Comparison of Cold-Related Conditions

Feature Hypothyroidism Anemia Raynaud's Phenomenon Poor Circulation (PAD)
Primary Cause Insufficient thyroid hormones Lack of healthy red blood cells/hemoglobin Exaggerated blood vessel spasms Plaque buildup in arteries
Affected Areas Generalized, entire body Hands and feet Digits (fingers and toes), sometimes nose/ears Legs, feet, hands, arms
Accompanying Symptoms Fatigue, weight gain, dry skin, depression Fatigue, weakness, pale skin, shortness of breath Skin color changes (white/blue/red), numbness, tingling Leg pain, cramps, sores, numbness, tingling
Symptom Pattern Persistent, generalized coldness Persistent, localized coldness Episodic, triggered by cold/stress Persistent, often worse with activity

Chronic Illnesses and Other Factors

Several chronic illnesses and other factors can influence temperature regulation and lead to cold sensitivity. Fibromyalgia, a chronic condition causing widespread pain, can increase a person's sensitivity to temperature changes. Chronic severe illness and general poor health can also disrupt the body's metabolic processes and thermal regulation.

Anorexia nervosa, a serious eating disorder, leads to significant weight loss and malnutrition, which drastically reduces the body's insulating fat and slows metabolism to conserve energy, resulting in severe cold intolerance. Even seemingly minor issues, such as a vitamin B12 deficiency without full-blown anemia, can affect nerve function and contribute to cold feelings.

When to Seek Medical Attention

If you have always been sensitive to cold, it may just be a personal tendency. However, if your cold intolerance is new, severe, persistent, or accompanied by other concerning symptoms, it is important to speak with a healthcare provider. A doctor can help determine if an underlying condition is the cause and recommend appropriate diagnostic tests, such as blood work to check thyroid function, iron levels, or blood sugar.

Many of these conditions, once diagnosed, can be effectively managed with medication, lifestyle adjustments, or nutritional changes, helping to resolve or significantly improve cold sensitivity. Never ignore persistent symptoms, as addressing the root cause is essential for improving your overall health and well-being.


For more information on cardiovascular diseases that can cause poor circulation, visit the American Heart Association website.

Frequently Asked Questions

Hypothyroidism, a condition where the thyroid gland is underactive and does not produce enough hormones to regulate your metabolism, is one of the most common causes of persistent cold intolerance.

Yes, iron deficiency can lead to anemia, which results in a lack of healthy red blood cells to carry oxygen throughout the body. This can cause you to feel cold, especially in your hands and feet.

Yes, poor circulation is a common cause of cold hands and feet. Conditions like Peripheral Artery Disease (PAD), which restricts blood flow, can lead to persistent coldness in the extremities.

In addition to feeling cold, Raynaud's can cause fingers and toes to feel numb and change color (white, then blue, then red) in response to cold temperatures or stress.

Yes, some medications, including certain beta-blockers, antidepressants, and medicines for migraines or ADHD, can interfere with blood flow or temperature regulation and cause cold sensitivity.

Yes, long-term uncontrolled diabetes can cause nerve damage (neuropathy) and circulation problems, which can lead to cold or numb sensations, particularly in the feet and hands.

If your cold sensitivity is new, severe, persistent, or accompanied by other symptoms like fatigue, weight changes, or skin discoloration, you should consult a doctor for a proper diagnosis.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.