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Why do lymph nodes in my armpit keep coming and going?

4 min read

Over 600 lymph nodes are scattered throughout the human body, acting as crucial filters for the immune system. When the lymph nodes in your armpit, known as axillary lymph nodes, keep coming and going, it signals an intermittent response from your immune system to various triggers, both common and rare.

Quick Summary

Intermittent armpit lymph node swelling, or axillary lymphadenopathy, is typically the immune system's reaction to recurrent or resolving infections, minor injuries, or allergic reactions. It can also point to autoimmune diseases or, less commonly, chronic infections, and warrants medical evaluation if persistent, painful, or accompanied by other symptoms.

Key Points

  • Immune System Response: Intermittent swelling of armpit lymph nodes usually indicates your body is reacting to an infection, inflammation, or injury in the upper body.

  • Common Causes Are Benign: Most recurring swelling is due to minor, temporary issues like skin infections (e.g., folliculitis), vaccine reactions, or allergic sensitivity to topical products.

  • Autoimmune Conditions Can Cause Fluctuation: Systemic issues such as lupus or rheumatoid arthritis can cause chronic inflammation that leads to waxing and waning lymphadenopathy.

  • Signs of Serious Concern: While rare, a hard, fixed, and painless lump that persists for several weeks, especially when accompanied by symptoms like weight loss or night sweats, warrants urgent medical attention.

  • Vaccinations as a Trigger: Recent vaccinations administered in the arm can cause a temporary and self-resolving immune response that includes armpit lymph node swelling.

  • Monitor and Consult: It is important to monitor the size, consistency, and duration of the swelling. Always consult a healthcare provider for a proper diagnosis, particularly if the swelling is persistent or unexplained.

In This Article

Understanding the Lymphatic System's Role

Your lymphatic system is a vital part of your immune system, comprising a network of vessels and nodes that transport a fluid called lymph. The lymph nodes in your armpits (axilla) are designed to filter this fluid, trapping harmful invaders like bacteria and viruses. When these nodes detect a threat, they fill with immune cells to fight it off, causing them to swell. Once the threat is neutralized, they shrink back to their normal size. The cycle of swelling and subsiding indicates an ongoing, but often successful, battle within your body.

Common Causes of Recurrent Swelling

Several common and less serious conditions can cause your armpit lymph nodes to repeatedly swell and shrink. These are often related to immune responses triggered by everyday occurrences.

Recurring Local Infections

Infections in the arm, hand, or breast can cause the nearby armpit lymph nodes to react. This can include:

  • Folliculitis: An infection or inflammation of hair follicles, often caused by shaving or waxing, leading to small, red bumps and localized swelling.
  • Boils: Painful, pus-filled lumps that develop around an infected hair follicle.
  • Hidradenitis suppurativa: A chronic inflammatory skin condition affecting sweat glands in the armpit and groin, causing recurrent, painful lumps and abscesses.
  • Minor cuts and scrapes: Infections from minor injuries on the arm or hand can trigger a temporary immune response in the axillary nodes.

Vaccinations and Allergic Reactions

Some vaccinations, particularly those injected in the arm, can cause a temporary immune response that includes localized lymph node swelling. The COVID-19 vaccine is a well-documented example. Similarly, allergic reactions to deodorants, soaps, or other topical products can cause intermittent swelling and inflammation in the armpit area.

Chronic Systemic Conditions

Some conditions can cause more widespread or persistent lymph node reactivity, even if the swelling seems to come and go.

  • Autoimmune diseases: Conditions such as lupus and rheumatoid arthritis cause the immune system to mistakenly attack healthy tissue, leading to chronic, systemic inflammation and enlarged lymph nodes in various areas, including the armpits.
  • Viral illnesses: While often causing temporary swelling, certain chronic or recurrent viral infections like Epstein-Barr virus (mononucleosis) or HIV can cause repeated or prolonged lymphadenopathy.

Less Common but More Serious Causes

While most cases of intermittent lymph node swelling are benign, some more serious conditions must be ruled out by a medical professional, especially if other symptoms are present.

Chronic Granulomatous Diseases

Diseases like sarcoidosis or tuberculosis can cause persistent or recurring lymph node enlargement as the body forms granulomas (clumps of immune cells) to wall off perceived threats.

Malignancies

Though rare, cancer can be a cause of axillary lymph node swelling, which may appear intermittent in some stages.

  • Lymphoma: This is a cancer of the lymphatic system itself, where abnormal lymphocytes multiply and accumulate in the lymph nodes.
  • Metastatic cancer: Cancers from other parts of the body, most notably breast cancer, can spread to the armpit lymph nodes.

Comparison of Common vs. Serious Lymph Node Swelling

Feature Common Causes (Infection/Injury) Serious Causes (Autoimmune/Cancer)
Onset Often rapid, linked to a recent illness or injury Can be gradual and insidious, without a clear trigger
Sensation Often tender or painful to the touch Frequently painless, even when large
Consistency Softer and mobile, like a pea or grape Firm, hard, or rubbery; may feel fixed and immovable
Duration Usually resolves within 2–4 weeks as illness passes Persistent, growing, or unchanging over several weeks
Associated Symptoms Fever, sore throat, cough, localized rash Unexplained weight loss, night sweats, persistent fever, fatigue

When to Seek Medical Attention

If you experience recurrent armpit lymph node swelling, it's wise to consult a doctor. While many causes are harmless, persistent or concerning signs warrant a professional evaluation. See a doctor if:

  • The swelling persists for more than a couple of weeks.
  • The lump is hard, fixed in place, or grows larger.
  • You experience associated symptoms like unexplained weight loss, night sweats, or a prolonged fever.
  • Swelling is occurring in multiple, non-adjacent areas of the body.
  • The area is red, inflamed, or draining.

What to Expect at Your Appointment

Your doctor will likely start with a physical exam and a detailed medical history. They may order blood tests to check for systemic infections or autoimmune markers. Imaging, such as an ultrasound or mammogram, might be used to examine the node and surrounding tissue more closely. In some cases, a biopsy—where a small tissue sample is taken—is necessary to get a definitive diagnosis. Early diagnosis is key for any potentially serious condition.

For more detailed health information, consult reliable medical sources like the Mayo Clinic, which offers extensive resources on common symptoms and conditions.

Conclusion: Your Body's Immune Message

Recurrent lymph node swelling in the armpit is, in most cases, your immune system's way of dealing with ongoing or repeated benign issues like skin irritation or minor infections. The key is to be observant of the swelling's characteristics and any accompanying symptoms. While often a normal process, any changes that suggest a more persistent or serious issue should prompt a visit to a healthcare provider. Paying attention to these signals is an important part of proactive health management.

Frequently Asked Questions

Yes, some people may have an allergic reaction or sensitivity to ingredients in deodorant or antiperspirants, which can cause intermittent inflammation and swelling of the nearby lymph nodes.

It can be, particularly if you have a recurring infection, like folliculitis from shaving, or a chronic inflammatory condition. The swelling indicates an active immune response, and it subsides as the body successfully manages the issue.

You should seek medical advice if the swelling lasts more than a couple of weeks, grows larger, feels hard and immovable, or is accompanied by other symptoms like unexplained weight loss, fever, or night sweats.

While stress doesn't directly cause lymph nodes to swell, chronic stress can weaken your immune system, making you more susceptible to minor infections that could then trigger a lymph node response. Anxiety can also make you hyperaware of normal lymph nodes.

Yes, it is common for a vaccine administered in the upper arm, such as the COVID-19 vaccine, to cause temporary lymph node swelling in the armpit as part of a normal immune response.

A swollen lymph node is part of the immune system and feels like a small, movable, pea-to-bean-sized bump. A cyst, like a sebaceous cyst, is a fluid-filled sac under the skin, which may feel different and usually requires a professional diagnosis to differentiate.

If a lymph node remains swollen for more than 2–4 weeks without shrinking, it could indicate a more chronic issue or potentially a more serious condition, and it should be evaluated by a healthcare professional.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.