Skip to content

What is the disease that makes you sweat at night?

5 min read

While millions of people experience night sweats, a condition where excessive sweating soaks through clothes and bedding, it can be a sign of a more serious underlying health problem, raising the question: What is the disease that makes you sweat at night?

Quick Summary

Night sweats are a symptom, not a disease itself, and can be caused by various medical conditions, including hormonal changes from menopause, specific cancers like lymphoma, and infections such as tuberculosis, among other possibilities.

Key Points

  • Night Sweats vs. Overheating: True night sweats are drenching episodes of sweating unrelated to your bedroom's temperature, unlike simple overheating.

  • Diverse Causes: Many conditions can cause night sweats, from hormonal fluctuations during menopause to infections like tuberculosis and certain cancers.

  • Hormonal Influence: Endocrine issues like hyperthyroidism and hypoglycemia can trigger excessive nighttime sweating by disrupting the body's internal thermostat.

  • Red Flag Symptoms: Accompanying symptoms like unexplained weight loss, fever, and fatigue alongside persistent night sweats warrant medical evaluation to rule out serious conditions like lymphoma.

  • Diagnosis is Key: A healthcare provider uses a thorough history and specific tests to uncover the root cause, which is the key to effective treatment.

  • Beyond Disease: Common medications, substance withdrawal, and lifestyle factors like anxiety or poor sleep can also be triggers.

In This Article

Understanding the Difference Between Night Sweats and Overheating

Many people occasionally wake up feeling hot and sweaty, which is often a normal response to a warm sleeping environment, too many blankets, or heavy sleepwear. However, true night sweats, also known as sleep hyperhidrosis, are defined by repeated episodes of drenching perspiration that soaks through your pajamas and sheets. These episodes occur regardless of a cool bedroom temperature and can be disruptive and distressing. While not always a sign of a serious illness, persistent night sweats are a symptom that should prompt a conversation with a healthcare provider to determine the root cause.

Hormonal Causes of Nocturnal Sweating

Menopause and Perimenopause

Hormonal fluctuations are one of the most common causes of night sweats, especially in women. During perimenopause and menopause, decreasing levels of estrogen and progesterone can disrupt the hypothalamus, the part of the brain that regulates body temperature. This can lead to hot flashes and night sweats that occur regularly. While often a normal part of life transition, the severity and frequency can vary significantly among individuals.

Other Endocrine Disorders

Beyond menopause, other endocrine (hormone-related) conditions can trigger excessive sweating.

  • Hyperthyroidism: An overactive thyroid gland produces too much thyroid hormone, which can speed up your body's metabolism and cause a general feeling of heat and excessive sweating.
  • Hypoglycemia: Low blood sugar can cause sweating, and for those with diabetes on insulin or other medications, nocturnal hypoglycemia can be a specific cause of night sweats.
  • Pheochromocytoma: This rare tumor of the adrenal gland can lead to episodes of sweating accompanied by headaches and a rapid heartbeat due to the overproduction of certain hormones.

Night Sweats as a Symptom of Infection

Several infections can cause persistent fevers and night sweats as the body's immune system fights off the pathogen.

  • Tuberculosis (TB): This is one of the most classic infectious causes of night sweats and is often accompanied by fever, fatigue, and unexplained weight loss.
  • HIV/AIDS: Night sweats are a common symptom for individuals with HIV.
  • Endocarditis: An infection of the heart valves, endocarditis can cause fever, chills, and night sweats.
  • Osteomyelitis: A bone infection can also lead to night sweats and other symptoms like bone pain and fever.

Cancer-Related Night Sweats: What to Know

While relatively rare, night sweats can be a symptom of certain cancers. These typically present with other warning signs.

  • Lymphoma: Both Hodgkin's and non-Hodgkin's lymphoma can cause night sweats, often in combination with fever and unexplained weight loss, known as “B symptoms.”
  • Leukemia: Cancers of the blood and bone marrow, such as leukemia, can also be associated with night sweats.

It is important to remember that night sweats caused by cancer are usually accompanied by other significant and noticeable symptoms. Experiencing night sweats alone is not an indication of cancer.

Other Conditions Linked to Night Sweats

Sleep Disorders

Sleep-related issues can also contribute to or cause night sweats.

  • Obstructive Sleep Apnea (OSA): This common sleep disorder, which causes repeated pauses in breathing during sleep, has been linked to night sweats. The mechanism is thought to be related to increased effort in breathing and changes in oxygen levels.

Anxiety and Stress

Chronic stress and anxiety can lead to a heightened state of alertness in the body's nervous system, causing an increase in heart rate and sweating. This physical response can persist during the night, leading to night sweats.

Gastroesophageal Reflux Disease (GERD)

Some research suggests a link between acid reflux and night sweats, though it is not a universally accepted cause. For some, treating GERD with medication has led to a reduction in night sweats.

Medications and Substance Use

Certain medications and substance use can trigger night sweats as a side effect. Some examples include:

  • Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are known to cause night sweats in some individuals.
  • NSAIDs: Some pain relievers can cause sweating.
  • Hormone Therapies: Medications used to manipulate hormone levels can have sweating as a side effect.
  • Substance Withdrawal: Stopping alcohol or certain drugs can lead to withdrawal symptoms, including night sweats.

Comparison of Potential Night Sweat Causes

Feature Menopause Infection (e.g., TB) Lymphoma Sleep Apnea
Associated Symptoms Hot flashes, irregular periods, mood swings Fever, unexplained weight loss, cough, fatigue Fever, unexplained weight loss, swollen lymph nodes Snoring, interrupted breathing, daytime fatigue
Frequency of Sweating Episodic hot flashes Persistent and drenching Persistent and drenching Varies; can be very frequent
Onset Gradually as a woman approaches menopause Often sudden, with other signs of infection Can be gradual or sudden Often gradual, worsens over time
Diagnostic Approach Medical history, hormone level testing Blood tests, chest x-ray, cultures Lymph node biopsy, imaging scans Polysomnography (sleep study)
Response to Treatment Hormone therapy, lifestyle changes Antibiotics Chemotherapy, radiation CPAP therapy

When to Consult a Healthcare Provider

While isolated incidents of night sweats are typically not a concern, you should contact a doctor if your night sweats are:

  1. Persistent, drenching, and recurring.
  2. Accompanied by a fever or unexplained weight loss.
  3. Present alongside other symptoms like fatigue or pain.
  4. Disrupting your sleep and quality of life.

A doctor can help rule out serious medical conditions and identify the cause of your symptoms. Don't hesitate to seek medical advice if you are concerned.

Diagnostic and Treatment Approaches

Diagnosing the cause of night sweats typically involves a thorough medical history, physical examination, and potentially specific tests based on your other symptoms. A doctor may perform:

  • Blood tests: To check for infection, hormone levels, or other systemic issues.
  • Imaging tests: Such as a chest X-ray or CT scan, if an infection or malignancy is suspected.
  • Polysomnography: A sleep study to check for sleep apnea.

Treatment depends entirely on the underlying cause. Options may range from medication adjustments and hormone therapy to managing an infection or a serious illness. For some, lifestyle changes, such as wearing breathable fabrics or managing stress, may offer relief. Understanding the cause is the first step toward effective management.

Learn more about night sweats and their causes from the Cleveland Clinic.

Conclusion: Taking Action on Night Sweats

Night sweats are a common but often unsettling symptom that points to a wide range of potential underlying causes. While simple environmental factors are sometimes to blame, persistent, drenching night sweats can be a signal from your body that something more significant is at play, including hormonal changes, infections, and certain malignancies. The key to effective management is accurate diagnosis, which requires a conversation with your healthcare provider. Identifying the specific disease or condition behind your nighttime sweating is the crucial first step toward finding relief and restoring your peace of mind and sleep quality.

Frequently Asked Questions

Night sweats involve soaking through your pajamas and bedding with excessive perspiration, regardless of the room temperature. Feeling hot is typically caused by a warm environment, but it doesn't result in drenching sweats.

Yes, chronic anxiety and stress can lead to an overactive sympathetic nervous system, causing physiological responses such as an increased heart rate and excessive sweating, which can occur during the night.

A variety of infections can cause night sweats, including tuberculosis (TB), HIV/AIDS, endocarditis, and bone infections like osteomyelitis, as the body fights off the invading pathogens.

You should see a doctor if your night sweats are persistent, drenching, and accompanied by other symptoms like unexplained weight loss, fever, or swollen lymph nodes. Seeking medical advice is important if the sweats are disrupting your sleep or causing concern.

Yes, many medications can cause night sweats as a side effect. Some common examples include certain antidepressants (SSRIs), hormone therapies, and anti-inflammatory drugs like NSAIDs.

Night sweats are rarely the only symptom of cancer. While they can be associated with certain types like lymphoma, they are typically accompanied by other signs such as unexplained weight loss and fever. Most night sweats have a less serious cause.

Hyperhidrosis is a condition of excessive, chronic sweating. Secondary hyperhidrosis can cause night sweats due to an underlying medical condition, while primary hyperhidrosis is excessive sweating not caused by another medical issue.

References

  1. 1
  2. 2
  3. 3
  4. 4

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.